If your business has more than one physical location, even in different states, you can now add multiple company work locations, for the same company under the same federal tax ID number. Each employee will be assigned a work location. When you run payrolls, the proper state and local taxes will be calculated for each employee.
If your business has employees who work primarily from home, you can indicate their home address as their work location, and taxes will be calculated accordingly.
For more details, see the following help articles: